Publications



  1. Kondo Y, Higa S, Iwasaki T, Matsumoto T, Maehara K, Harada A, Baba Y, Fujita M, Ohkawa Y. Sensitive detection of fluorescence in western blotting by merging images. PLoS One. e0191532 (2018).

  2. Hosen N, Matsunaga Y, Hasegawa K, Matsuno H, Nakamura Y, Makita M, Watanabe K, Yoshida M, Satoh K, Morimoto S, Fujiki F, Nakajima H, Nakata J, Nishida S, Tsuboi A, Oka Y, Manabe M, Ichihara H, Aoyama Y, Mugitani A, Nakao T, Hino M, Uchibori R, Ozawa K, Baba Y, Terakura S, Wada N, Morii E, Nishimura J, Takeda K, Oji Y, Sugiyama H, Takagi J, Kumanogoh A. The activated conformation of integrin β7 as a target for multiple myeloma-specific chimeric antigen receptor T cell therapy. Nat. Med. 12, 1436-1443. (2017).

  3. Ohba T, Watanabe H, Murakami M, Iino K, Adachi T, Baba Y, Kurosaki T, Ono K, Ito H. Stromal interaction molecule 1 haploinsufficiency causes maladaptive response to pressure overload. PLoS One. 12, e0187950 (2017).

  4. Lim HM, Woon H, Han JW, Baba Y, Kurosaki T, Lee MG, Kim JY. UDP-Induced Phagocytosis and ATP-Stimulated Chemotactic Migration Are Impaired in STIM1-/- Microglia In Vitro and In Vivo. Mediators Inflamm. 8158514 (2017).

  5. Morimoto K, *Baba Y, Shinohara H, Kang S, Nojima S, Kimura T, Ito D, Yoshida Y, Maeda Y, Sarashina-Kida H, Nishide M, Hosokawa T, Kato Y, Hayama Y, Kinehara Y, Okuno T, Takamatsu H, Hirano T, Shima Y, Narazaki M, Kurosaki T, *Toyofuku T & Kumanogoh A. LRRK1 is critical in the regulation of B-cell responses and CARMA1-dependent NF-κB activation. Sci. Rep. 6, 25738 (2016).

  6. Ohmi Y, Ise W, Harazono A, Takakura D, Fukuyama H, Baba Y, Narazaki M, Shoda H, Takahashi N, Ohkawa Y, Ji S, Sugiyama F, Fujio K, Kumanogoh A, Yamamoto K, Kawasaki N, Kurosaki T, Takahashi Y & *Furukawa K. Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis. Nat. Commun. 7, 11205 (2016).

  7. *Baba Y & Kurosaki T. Role of Calcium Signaling in B Cell Activation and Biology. Curr. Top. Microbiol. Immunol. 393, 143-174 (2016).

  8.  *Baba Y, Matsumoto M & Kurosaki T. Signals controlling the development and activity of regulatory B-lineage cells. Int. Immunol. 10, 487-493 (2015).

  9. Shanmughapriya S, Rajan S, Hoffman N, Zhang X, Guo S, Kolesar J, Hines K, Ragheb J, Kaufman B, Baba Y, Zhou Y, Cheung J, Kurosaki T, Gill DL & *Madesh M. Ca2+ signals control function and CREB-mediated expression of the mitochondrial Ca2+ uniporter. Sci. Signal 8, ra23 (2015).

  10.  Matsumoto M, Baba A, Yokota T, Nishikawa H, Ohkawa Y, Kayama H, Kallies A, Nutt SL, Sakaguchi S, Takeda K, *Kurosaki T & *Baba Y. Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation. Immunity 41, 1040-1051 (2014).

  11. Hendron E, Wang X, Zhou Y, Cai X, Goto JI, Mikoshiba K, & Baba Y, Kurosaki T, Wang Y & Gill DL. Potent functional uncoupling between STIM1 and Orai1 by dimeric 2-aminodiphenyl borinate analogs. Cell Calcium 56, 482-492 (2014).

  12. Hartmann J, Karl RM, Alexander RP, Adelsberger H, Brill MS, Rühlmann C, Ansel A, Sakimura K, Baba Y, Kurosaki T, Misgeld T & Konnerth A. STIM1 controls neuronal Ca2+ signaling, mGluR1-dependent synaptic transmission, and cerebellar motor behavior. Neuron 82, 635-644 (2014).

  13. Masahata K, Umemoto E, Kayama H, Kotani M, Nakamura S, Kurakawa T, Kikuta J, Gotoh K, Motooka D, Sato S, Higuchi T, Baba Y, Kurosaki T, Kinoshita M, Shimada Y, Kimura T, Okumura R, Takeda A, Tajima M, Yoshie O, Fukuzawa M, Kiyono H, Fagarasan S, Iida T, Ishii M & Takeda K. Generation of colonic IgA-secreting cells in the caecal patch. Nat. Commun. 5, 3704 (2014).

  14. Furukawa Y, Teraguchi S, Ikegami T, Dagliyan O, Jin L, Hall D, Dokholyan N, Namba K, Akira S, Kurosaki T, Baba Y & Standley D. Intrinsic disorder mediates cooperative signal transduction in STIM1. J. Mol. Biol. 426, 2082-2097 (2014).

  15. Zhang H, Clemens RA, Liu F, Hu Y, Baba Y, Theodore P, Kurosaki T, & Lowell CA. The STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense. Blood 123, 2238-2249 (2014).

  16. Baba Y, Matsumoto M & Kurosaki T. Calcium signaling in B cells: Regulation of cytosolic Ca2+ increase and its sensor molecules, STIM1 and STIM2. Mol. Immunol. 62, 339–343 (2014).

  17. Fujii Y, Shiota M, Ohkawa Y, Baba A, Wanibuchi H, Kinashi T, Kurosaki T & *Baba Y. Surf4 modulates STIM1-dependent calcium entry. Biochem. Biophys. Res. Commun. 422, 615-620 (2012).

  18. *Baba Y & Kurosaki T. The impact of Ca2+ signaling on B cell function. Trends. Immunol. 32, 589-594 (2011).

  19. Matsumoto M, Fujii Y, Baba A, Hikida M, Kurosaki T & *Baba Y. The Calcium Sensors STIM1 and STIM2 Control B cell Regulatory Function through Interleukin-10 Production. Immunity 34, 703-714 (2011).

  20. Hawkins BJ, Irrinki KM, Mallilankaraman K, Lien YC, Wang Y, Bhanumathy CD, Subbiah R, Ritchie MF, Soboloff J, Baba Y, Kurosaki T, Joseph SK, Gill DL & Madesh M. S-glutathionylation activates STIM1 and alters mitochondrial homeostasis. J. Cell Biol. 190, 391-405 (2010).

  21. Kurosaki T & Baba Y. Ca2+ signaling and STIM1. Prog. Biophys. Mol. Biol. 103, 51-58 (2010).

  22. Kurosaki T, Shinohara H & Baba Y. B Cell Signaling and Fate Decision. Annu. Rev. Immunol. 28, 21-55 (2010).

  23. *Baba Y & Kurosaki T. Physiological function and molecular basis of STIM1-mediated calcium entry in immune cells. Immunol. Rev. 231, 174-188 (2009).

  24. Wang Y, Deng X, Zhou Y, Hendron E, Mancarella S, Ritchie MF, Tang XD, Baba Y, Kurosaki T, Mori Y, Soboloff J & Gill DL. STIM protein coupling in the activation of Orai channels. Proc. Natl. Acad. Sci. U S A. 106, 7391-7396 (2009).

  25. Morita T, Tanimura A, Baba Y, Kurosaki T & Tojyo Y. A Stim1-dependent, noncapacitative Ca2+-entry pathway is activated by B-cell-receptor stimulation and depletion of Ca2+. J. Cell Sci. 122, 1220-1228 (2009).

  26. Malhotra S, Baba Y, Garrett KP, Staal FJ, Gerstein R & Kincade PW. Contrasting responses of lymphoid progenitors to canonical and noncanonical wnt signals. J. Immunol. 181, 3955-3964 (2008).

  27. Baba Y, Nishida K, Fujii Y, Hirano T, Hikida M & Kurosaki T. Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses. Nat. Immunol. 9, 81-88 (2008).

  28. Baba Y, Hayashi K, Fujii Y, Mizushima A, Watarai H, Wakamori M, Numaga T, Mori Y, Iino M, Hikida M & Kurosaki T. Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum. Proc. Natl. Acad. Sci. USA 103, 16704-16709 (2006).

  29. Baba Y, Yokota T, Spits H, Garrett KP, Hayashi S & Kincade PW. Constitutively active β-catenin promotes expansion of multipotent hematopoietic progenitors in culture. J. Immunol. 177, 2294-2303 (2006).

  30. Igarashi H#, Baba Y# (#contributed equally), Nagai Y, Jimi E, Ghosh S & Kincade PW. NF-κB is dispensable for normal lymphocyte development in bone marrow but required for protection of progenitors from TNFα. Int. Immunol. 18, 653-659 (2006). 

  31. Baba Y, Garrett KP & Kincade PW. Constitutively active β-catenin confers multilineage differentiation potential on lymphoid and myeloid progenitors. Immunity 23, 599-609 (2005).

  32. Maeda K, Baba Y, Nagai Y, Miyazaki K, Malykhin A, Nakamura K, Kincade PW, Sakaguchi N & Coggeshall KM. IL-6 blocks a discrete early step in lymphopoiesis. Blood 106, 879-885 (2005).

  33. Pelayo R, Welner R, Perry SS, Huang J, Baba Y, Yokota T & Kincade PW. Lymphoid progenitors and primary routes to becoming cells of the immune system. Curr. Opin. Immunol. 17, 100-107 (2005).

  34. Baba Y, Pelayo R & Kincade PW. Relationships between hematopoietic stem cells and lymphocyte progenitors. Trends. Immunol. 25, 645-649 (2004).

  35. Kawakami M, Kimura T, Kishimoto Y, Tatekawa T, Baba Y, Nishizaki T, Matsuzaki N, Taniguchi Y, Yoshihara S, Ikegame K, Shirakata T, Nishida S, Masuda T, Hosen N, Tsuboi A, Oji Y, Oka Y, Ogawa H, Sonoda Y, Sugiyama H, Kawase I & Soma T. Preferential expression of the vasoactive intestinal peptide (VIP) receptor VPAC1 in human cord blood-derived CD34+CD38- cells: possible role of VIP as a growth-promoting factor for hematopoietic stem/progenitor cells. Leukemia 18, 912-921 (2004).

  36. Watanabe D, Hashimoto S, Ishiai M, Matsushita M, Baba Y, Kishimoto T, Kurosaki T & Tsukada S. Four tyrosine residues in phospholipase C-γ2, identified as Btk-dependent phosphorylation sites, are required for B cell antigen receptor-coupled calcium signaling. J. Biol. Chem. 276, 38595-38601 (2001).

  37. Tsukada S, Baba Y & Watanabe D. Btk and BLNK in B cell development. Adv. Immunol. 77, 123-162 (2001).

  38. Futatani T, Watanabe C, Baba Y, Tsukada S & Ochs HD. Bruton's tyrosine kinase is present in normal platelets and its absence identifies patients with X-linked agammaglobulinaemia and carrier females. Br. J. Haematol. 114, 141-149 (2001).

  39. Baba Y, Hashimoto S, Matsushita M, Watanabe D, Kishimoto T, Kurosaki T & Tsukada S. BLNK mediates Syk-dependent Btk activation. Proc. Natl. Acad. Sci. USA 98, 2582-2586 (2001).

  40. Baba Y, Matsushita M, Matsuda Y, Inazawa J, Yamadori T, Hashimoto S, Kishimoto T & Tsukada S. Assignment of SH3BP5/Sh3bp5 encoding sab, an SH3 domain-binding protein which preferentially associates with Bruton's tyrosine kinase, to human chromosome 1q43 and mouse chromosome 14B by in situ hybridization. Cytogenet. Cell. Genet. 87, 221-222 (1999).

  41. Hashimoto S, Iwamatsu A, Ishiai M, Okawa K, Yamadori T, Matsushita M, Baba Y, Kishimoto T, Kurosaki T & Tsukada S. Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling. Blood 94, 2357-2364 (1999).

  42. Yamadori T, Baba Y, Matsushita M, Hashimoto S, Kurosaki M, Kurosaki T, Kishimoto T & Tsukada S. Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein. Proc. Natl. Acad. Sci. USA 96, 6341-6346 (1999).

  43. Baba Y, Nonoyama S, Matsushita M, Yamadori T, Hashimoto S, Imai K, Arai S, Kunikata T, Kurimoto M, Kurosaki T, Ochs HD, Yata J, Kishimoto T & Tsukada S. Involvement of wiskott-aldrich syndrome protein in B-cell cytoplasmic tyrosine kinase pathway. Blood 93, 2003-2012 (1999).

  44. Matsushita M, Yamadori T, Kato S, Takemoto Y, Inazawa J, Baba Y, Hashimoto S, Sekine S, Arai S, Kunikata T, Kurimoto M, Kishimoto T & Tsukada S. Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (Btk). Biochem. Biophys. Res. Commun. 245, 337-343 (1998).

  45. Sagara J, Tochikura T. S, Tanaka H, Baba Y, Tsukita S, Tsukita S & Kawai A. The 21-kDa polypeptide (VAP21) in the rabies virion is a CD99-related host cell protein. Microbiol. Immunol. 42, 289-297 (1998).


総説・著書

  1. 馬場義裕:「抗体の多様性」「抗体のクラススイッチ」「B細胞抗原受容体」「抗原ー抗体反応と免疫複合体」免疫ペディア 第4章(羊土社) 2017
  2. 馬場義裕:「B細胞ストア作動性カルシウム流入による自己免疫性炎症反応の制御機構」YAKUGAKU ZASSHI 薬学雑誌136(3):473-478, 2016
  3. 馬場義裕:「免疫反応を抑制するB細胞:制御性B細胞」ライフサイエンス領域融合レビュー 2016
  4. 馬場義裕:「B細胞による腫瘍制御」The Frontiers in Life Sciences がんと免疫 (南山堂)84-94, 2015
  5. 馬場義裕、黒崎知博:「IL-10産生B細胞による自己免疫疾患の制御」実験医学増刊号 自己免疫疾患 (羊土社)vol.33 No. 12, 173-178, 2015
  6. 松本真典、黒崎知博、馬場義裕:「インターロイキン10を産生するプラズマブラストは自己免疫疾患における炎症反応を抑制する」ライフサイエンス 新着論文レビュー 2014年12月24日
  7. 馬場義裕:「B細胞からのIL-10産生機序」臨床免疫・アレルギー科(科学評論社) vol. 60 (3) 346-350, 2013
  8. 松本真典、馬場義裕:「制御性B 細胞におけるSTIM依存的カルシウム流入の役割」薬学雑誌 133(4): 419 -425, 2013
  9. 馬場義裕、黒崎知博:「B細胞のCa2+シグナルと自己免疫性炎症反応の抑制」医学のあゆみ(医歯薬出版社) vol 240 (3):243-244, 2012
  10. 馬場義裕:「ストア作動性カルシウムチャネル」細胞(ニューサイエンス社)43 (11), 20-23, 2011
  11. 馬場義裕:「小胞体Ca2+センサーであるSTIM1とSTIM2の誘導するCa2+流入がB細胞のインターロイキン10産生および炎症抑制機能に必須である」ライフサイエンス 新着論文レビュー 2011
  12. 馬場義裕:「免疫細胞におけるストア作動性カルシウム流入の役割」日本薬理学雑誌Vol:137(5),192-196, 2011
  13. 馬場義裕:「トランスポートソームの世界:免疫系」京都廣川書店142-149, 2011
  14. 馬場義裕、黒崎知博:「STIM1によるカルシウム応答の制御機構」生化学 Vol.80, No.12,1123-1128, 2008
  15. 馬場義裕、黒崎知博:「マストセルの小胞体カルシウムセンサー」感染・炎症・免疫vol.38 No.4, 78-81, 2008
  16. 馬場義裕、黒崎知博:Ca2+シグナルとSTIM1;実験医学増刊シグナル伝達研究2008-2009(羊土社)Vol26 (15):26-33, 2008
  17. 馬場義裕:小胞体Ca2+センサーSTIM1が誘導するCa2+流入がマスト細胞活性化に必須である;実験医学Vol26 No.8 Current Topics(羊土社):1253-1256, 2008.
  18. 馬場義裕、塚田聡:Tecファミリーキナーゼ; 新用語ライブラリー免疫(羊土社):122-123, 1999.
  19. 馬場義裕、塚田聡:無ガンマグロブリン血症とBtk; 遺伝子医学(メディカルドウ)3(3), 124-126, 1999.
  20. 塚田聡、馬場義裕:BtkとWASP-2つの免疫不全症責任遺伝子の連関; 免疫1998-99(中山書店)35:216-224, 1998.
  21. 馬場義裕、塚田聡:最近わかった先天性免疫不全症の責任遺伝子;感染・炎症・免疫 (医薬の門社)27(4):39-41, 1997.
  22. 馬場義裕、塚田聡:Btk;ノックアウトマウス・データブック(中山書店):61-62, 1997.
  23. 馬場義裕、塚田聡:BtkとB細胞分化; 医学のあゆみ(医歯薬出版社)181(2):133-137, 1997.
  24. 馬場義裕、塚田聡:先天性免疫グロブリン異常症; Molecular Medicine : 分子医学を臨床へ(中山書店)34(1):72-85, 1997.
  25. 馬場義裕、塚田聡:B細胞分化と免疫不全症;細胞工学(秀潤社)15:2, 1996.